Post-traumatic epilepsy (PTE) is a form of acquired epilepsy that results from brain damage caused by physical trauma to the brain (traumatic brain injury, abbreviated TBI). The current project titled "Targeting epileptogenic effects of subarachnoid blood in TBI" focuses on PTE caused by subarachnoid hemorrhage (SAH) in both human and rodent species. The database contains the research data agreegated for this project.
A major challenge in studying TBI relates to the high variability of extent, location, and complexity of injuries in both humans and animal models. In order to meaningfully advance our understanding and prevent epilepsy after TBI, it is critical to define the role of the different components of TBI in epileptogenesis. While there are both parenchymal and hemorrhagic components, SAH is readily measurable and very common, presenting in almost all severe TBIs. In fact, an estimated 40% of patients with moderate to severe head injuries may have SAH. Similarly, in animal models of TBI and blast injuries, subarachnoid bleeding is almost always seen grossly and histologically. In addition, SAH is known to produce seizures in humans and animals. These observations are coupled with elegant work implicating blood and blood products as highly epileptogenic. Previous research supports this implication with epilepsy developing in 3 - 25% of people following SAH.
Aim 1. Identification of early EEG, imaging, laboratory, and clinical findings that predict who develops epilepsy following subarachnoid hemorrhage (SAH).
Aim 2. An animal model of SAH and epileptogenesis.
Aim 3. Common EEG biomarkers in humans and in animal models.
Please login to access the patient and animal dataset. If you are not a registered user, please reach out to project PI for access.